Pathophysiology of Thrombosis - . The coronary at the right is even worse with evidence for previous thrombosis with organization of the thrombus and recanalization such that there are three small lumens remaining. Pathogenesis of Thrombosis. department of neurosciences canberra hospital march 1999. cerebral venous, chapter 32 Viral Pathogenesis - . definition. 1865: Molecular pathogenesis of subarachnoid haemorrhage - . Patients with cirrhosis have a hyperdynamic circulation. “Response-to-Injury Hypothesis” for Development of Atherosclerosis 4. •Virchow's triad (1845) postulated that thrombosis results from alterations in vessel wall, blood flow, and properties of blood. The clot, thrombus, does not move to different parts of the body. The dominant influence, and the one factor that by itself can lead to thrombosis, is endothelial injury.2,5,6 Endothelial Injury: Endothelial injury causes subendothelial collagen exposure and platelet adherence, among other changes; many factors can contribute to the injury, including hypertension, vasculitis, scarred valves, bacterial endotoxins, cholesterolemia, and chemicals … Coronary artery with mild atherosclerosis and some fatty streaks. Tissue factor is a substance present in tissue, Blocks conversion of prothrombin to thrombin, LOWER MORTALIT RATE WITH TPA VERSUS STREPTOKINASE, HIGHER RISK OF INTRACRANIAL BLEEDING WITH TPA, DOSE- INITIAL BOLUS OF 15 MG IV, THEN 0.75 MG/KG, NO CHANGE ON MORTALITY COMPARED TO STREPTOKINASE, DOSE- 10 UNITS GIVEN OVER 2 MIN THEN REPEATED, THIRD GENERATION VARIANT OF THE t-PA MOLECULE, RESISTANCE TO PLASMINOGEN ACTIVATOR INHIBITOR, TNKASE BINDS TO FIBRIN AND CONVERTS PLASMINOGEN, THROMBOLYTIC THERAPY CLASS IF CLINICAL COMPLAINTS, DOOR TO DRUG TIME GOAL lt THAN 30 MINUTES, CONSIDERED CLASS II a IF PATIENTS GREATER THAN 74, INTRACRANIAL OR INTRASPINAL SURGERY WITHIN 2, RECENT ADMINISTRATION OF GP IIB/IIIA INHIBITORS. •Vessel wall •Blood flow •Properties of blood. Risk Factors (cont’d) •Diabetes mellitus induces hypercholesterolemia. Examples of Atherosclerosis of Human Arteries Microscopically, the aortic atheromatous plaque is thicker than the remaining media at the right. Pathophysiology of thrombosis "Virchow’s Triad” is a term for three broad categories of risk factors that predispose to thrombosis. Thrombus nearly occluding the lumen of the carotid artery. It can result in long-term complications that include postthrombotic syndrome (PTS) adding to its morbidity. Arterial thrombosis may be caused by a hardening of the arteries, called arteriosclerosis. These have thin fibrin caps that are prone to rupture. The plaque contains amorphous pink material with slit-like "cholesterol clefts" of lipid material. by imavi shanaya.w. 72, 87-90 In addition, anticoagulation for arterial events and atrial fibrillation may be required. Overview of Approach to Treatment •The optimal approach to the prevention and treatment of thromboembolic disease differs depending on whether the process involves thevenous or arterial circulation. They are all artistically enhanced with visually stunning color, shadow and lighting effects. A blood clot is formed in a blood vessel, obstructing blood flow. This plaque can suddenly burst (rupture), followed by a blood clot. basic skeletal structures & functions. A solid understanding of the pathophysiology of blood coagulation is essential in the practice of both medicine and surgery. COVID-19 infection is associated with high morbidity and mortality largely due to respiratory failure, with microvascular pulmonary thrombosis or PE originating from the leg veins playing an additional important pathophysiological role. Examples of Atherosclerosis of Human Arteries This is a normal coronary artery with no atherosclerosis and a widely patent lumen that can carry as much blood as the myocardium requires. Clinically, the role of vessel wall damage in the pathogenesis of venous thrombosis is uncertain at this time, but immobility plus increased coagulability is recognized as a major risk factor. •Smoking is a major risk factor and is thought to account for the recent increase in the incidence and severity of AS in women. thrombus formation in deep veins of legs or thighs. Arterial Thrombosis Venous. How- symptoms . The APEX Trial Investigators; Associate Editor(s)-in-Chief: Rim Halaby, M.D. Thrombosis - . - Clinical pathophysiology of the digestive system Clinical syndromes in liver injury Lack of liver disorders ... (involved in carbohydrate, fat, protein ... PATHOPHYSIOLOGY of TOBACCO-RELATED DISEASE, - pathophysiology of tobacco-related disease, Pathophysiology of acute and chronic renal failure, - Pathophysiology of acute and chronic renal failure Renata P ov, - PATHOPHYSIOLOGY OF BURNS Dr. Shiara Ortiz-Pujols Burn Fellow NC Jaycee Burn Center, Pathophysiology of digestion. Atherosclerosis •No disease in the U.S. is responsible for more deaths and has engendered more controversy than atherosclerosis (AS). •Lowering cholesterol, especially LDL-C (so called “bad cholesterol”), is clearly a good thing. Risk Factors (cont’d) •Hyperlipidemiais acknowledged to be a major risk factor for AS. Get powerful tools for managing your contents. – Thrombosis of an artery leading to the heart causes a myocardial infarction – Thrombosis of an artery leading to the brain causes a stroke. - SHOCK , PATHOPHYSIOLOGY Prof.M.H.MUMTAZ. doi: 10.17226/20259. The causes of thrombosis include vessel wal … Pathophysiology and diagnosis of deep venous thrombosis Semin Nucl Med. In The Most Common Inpatient Problems in Internal Medicine, 2007. Atherosclerosis is the development of plaques, or fatty hardenings, on the inner wall of … - CrystalGraphics offers more PowerPoint templates than anyone else in the world, with over 4 million to choose from. Disseminated intravascular coagulation (DIC) - . Entamoeba histolytica Pathogenesis and pathology - . Or use it to upload your own PowerPoint slides so you can share them with your teachers, class, students, bosses, employees, customers, potential investors or the world. J Thromb Haemost 2010; 8: 1886–94. The first step in COVID-19 pathogenesis is viral invasion via its target host cell receptors. •The most effective way to prevent arterial thrombosis is to prevent the underlying atherosclerosis. Stent thrombosis: evidence from a network meta-analysis - . SARS-CoV-2 viral entry has been described in detail elsewhere . Neutralization of activated coagulation factors by endothelial cell-bound components; 3. Inappropriate thrombus formation is a disruption of homeostasis and may result from an alteration in any of the factors listed below. Overview of Approach to Treatment (cont’d) •Thrombotic complications of coronary atherosclerosis and cerebral arteriosclerosis can be reduced by antiplatelet drugs (i.e., aspirin). Neutralization of activated coagulation factors by naturally occurring protease inhibitors; 4. And, best of all, most of its cool features are free and easy to use. HMG-CoA (3-Hydroxy-3-methylglutaryl-CoA) Lovastatin Statins (cont’d) •One of the drugs used today is shown below next to HMG-CoA: Lipids from diet Chylomicrons Remnants Lipoprotein lipase VLDL Peripheral cell Remnants LDL-R Cholesterol LDL LRP LDL-R Hepatic lipase Cholesterol Cholesterol-ester Transport protein Bile acids Cholesterol HDL Liver Statins (cont’d), Lipids from diet Chylomicrons Remnants Lipoprotein lipase VLDL Peripheral cell Remnants LDL-R Cholesterol LDL LRP LDL-R Hepatic lipase Cholesterol Cholesterol-ester Transport protein Bile acids Cholesterol HDL Liver Statins (cont’d). In the pathogenesis of arterial thrombosis, platelet aggregation is responsible for the initial flow obstruction but fibrin formation is necessary for the subsequent stabilization of the platelet-rich thrombosis. •Atherosclerosis appears to be a chronic inflammatory condition that is converted to an acute clinical event by the induction of plaque rupture, which in turns leads to thrombosis and death. jørn dalsgaard nielsen thrombosis centre gentofte hospital denmark. Bleeding and Thrombosis Disorders in the ICU - . Point of intervention Smoking Blood pressure Cholesterol Obesity Other factors Risk Thrombosis Heart attack Management and Prevention (cont’d). Thrombosis: The Critical Role of the Lab Paul Riley, PhD, MBA, Diagnostica Stago, Inc. Learning Objectives Describe the basic pathophysiology of DIC Demonstrate a diagnostic and management approach for DIC Compare markers of thrombin & plasmin generation in DIC, including D-Dimer, And they’re ready for you to use in your PowerPoint presentations the moment you need them. 1969. Pathophysiology of liver, - Title: Pathophysiology of digestion Author: User Last modified by: User Created Date: 1/7/2012 8:47:06 AM Document presentation format: (4:3), VASCULATURE, HEMODYNAMICS AND THEIR PATHOPHYSIOLOGY. 5 PREVENTION AND MANAGEMENT OF THROMBOSIS IN LIVER DISEASES. It is commonly caused by a venous thrombus that has dislodged from its site of formation and embolized to the arterial blood supply of one of the lungs. •Statins lower serum LDL-C concentrations by up-regulating LDL-receptor activity and by reducing entry of LDL into the circulation. Introduction. Thrombin in turn converts fibrinogen to fibrin. Pathophysiology. SHOCK , PATHOPHYSIOLOGY Prof.M.H.MUMTAZ. • Thrombosis is the activation of hemostasis at an inappropriate time and in an inappropriate blood vessel. division of critical care medicine university of alberta. •Hypertension is a major risk factor for atherosclerosis and may well be more important than hypercholesterolemia after age 45. •Myotoxicity is even rarer. viral pathogenesis is the process by which a viral infection leads to disease. Abnormalities of blood flow or venous stasis normally occur after prolonged immobility or confinement to bed. giuseppe biondi zoccai, md department of medico-surgical, Cerebral Venous Thrombosis - . Well-defined familial predisposition such as hypertension and diabetes. Fibrinogen is a plasma protein that converts to, Plasminogen is a plasma glycoprotein that, Plasmin is an enzyme that dissolves fibrin, Von Willebrand Factor is a protein stored in, Collagen fibers are the white protein fibers. They'll give your presentations a professional, memorable appearance - the kind of sophisticated look that today's audiences expect. Do you have PowerPoint slides to share? Learn about the symptoms and treatment of this condition. Mechanism of Cholesterol-lowering Drugs •Cholesterol is generally thought to be the major contributor to atherosclerosis. - Pathophysiology of digestion MD, Prof. Yu.I. Summary. Here is occlusive coronary atherosclerosis. tibial veins, soleal/gastrocnemius veins. •Sometimes there is myopathy, rash, peripheral neuropathy, insomnia, bad or vivid dreams, and difficulty sleeping or concentrating. Create stunning presentation online in just 3 steps. Prof. J. Plevkova MD, PhD. There is overlying recent hemorrhage at the left. Our new CrystalGraphics Chart and Diagram Slides for PowerPoint is a collection of over 1000 impressively designed data-driven chart and editable diagram s guaranteed to impress any audience. × Genetic derangements in lipoprotein metabolism, prototype is familial hypercholesterolemia. Pathogenesis of Venous Thrombosis Venous thromboembolism, ie, venous thrombosis and pulmonary embolism, represents a serious and potentially fatal complication for many sick, hospitalized patients, especially those who are bedridden for extended periods of time. Risk Factors •Prevalence and severity of the disease are related to many factors, some constitutional but others are acquired and potentially controllable. - PATHOPHYSIOLOGY OF HEPATIC FAILURE Assoc. Overview. •Constitutional factors are age, sex, and genetics: Age. © 2020 SlideServe | Powered By DigitalOfficePro, - - - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - - -. Retinal vein thrombosis: pathogenesis and management M. REHAK and P. WIEDEMANN Department of Ophthalmology, University of Leipzig, Leipzig, Germany To cite this article: Rehak M, Wiedemann P. Retinal vein thrombosis: pathogenesis and management. Cancer- Associated Thrombosis CAT - . •Virchow's triad (1845) postulated that thrombosis results from alterations in vessel wall, blood flow, and properties of blood. Many of the monocytes mature to macrophages. Energy Metabolism Perfusion Shock Topics Define shock in terms of cellular function Review the requirements for adequate ... - Lack of sufficient oxygen (single most common cause of cellular injury) Causes ... Pernicious Anemia. - Predictors of Acute, Subacute and Late Stent Thrombosis After Acute MI Primary Angioplasty in the Horizons AMI Trial George D. Dangas, Alexandra J. Lansky, Early and late coronary stent thrombosis of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice: data from a large two-institutional cohort study. Or use it to create really cool photo slideshows - with 2D and 3D transitions, animation, and your choice of music - that you can share with your Facebook friends or Google+ circles. Dilution of activated coagulation factors and disruption of platelet aggregates by blood flow; 5. formation of a clot within a vein occurs when there is i ) venous stasis ii)vessel injury, Discuss the pathogenesis and imaging approach of acromegaly and gigantism - . D., M D. Nataliya Potikha Regulation of arterial pressure ( P) CO leads to PR and P ... - Title: Neurological Pathophysiology Author: Yu Last modified by: Yu, Min Created Date: 2/10/2004 2:52:52 PM Document presentation format: On-screen Show (4:3). That's all free as well! - DEEP VENOUS THROMBOSIS DR.SHERAZ AHMED Definition Deep vein thrombosis is the formation of a blood clot in one of the deep veins of the body, usually in the leg ... | PowerPoint PPT presentation | free to view. • Formation of a blood clot in an artery or vein of a living person • Arterial thrombosis denies oxygen and nutrition to an area of the body. incidence pathogenesis predisposing, Deep Venous Thrombosis and its Complications - . 5.Cytokines and growth factors, affect some of the T-cells to undergo replication. Displaying pathogenesis of thrombosis PowerPoint Presentations Thrombosis Judoctors PPT Presentation Summary : The propagating portion of a thrombus is poorly attached ... blood (can potentially distinguish antemortem thrombosis from postmortem clots) postmortem blood Arterial thrombosis is often associated with atherosclerosis. PPT – Pathophysiology of Thrombosis PowerPoint presentation | free to download - id: 3d624e-Y2QzZ, The Adobe Flash plugin is needed to view this content. This can lead to a buildup of fatty material (called plaque) in the artery walls. treatments. Pathophysiology of Thrombosis Thrombosis and Thrombolysis in Acute Coronary Syndromes Blood Components - Platelets Contain adhesive glycoproteins GP Ia binds ... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 3d624e-Y2QzZ Deep vein thrombosis (DVT) occurs when a blood clot (thrombus) forms in one or more of the deep veins in your body, usually in your legs. Winner of the Standing Ovation Award for “Best PowerPoint Templates” from Presentations Magazine. In brief, SARS-CoV-2 consists of four main structural glycoproteins: spike (S), membrane (M), envelope (E), and nucleocapsid (N). causes. Departments of Pathology and Medicine Division of Cardiology David Geffen School of Medicine at UCLA – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 3f4967-MzFiM Condition. - Pathophysiology of vascular tone. Examples of Atherosclerosis of Human Arteries The degree of atherosclerosis is much greater in this coronary artery, and the lumen is narrowed by half. •Thrombolytic therapy has proven to be very successful in lysing acute coronary thrombi and has had a dramatic effect in reducing mortality after acute myocardial infarction (time to treatment is important). “Response-to-Injury Hypothesis” for Development of Atherosclerosis  7. •Given alone for primary or secondary prevention of heart disease, these drugs can reduce the incidence of coronary artery disease by 25 – 60% and reduce the risk of death from any cause by ~30%. Embolism. A coronary thrombosis is seen microscopically occluding the remaining small lumen of this coronary artery. CrystalGraphics 3D Character Slides for PowerPoint, - CrystalGraphics 3D Character Slides for PowerPoint. - Clinical Pathophysiology Of Cardiovascular Diseases Ph. Atherosclerosis--Basic Mechanisms •Atherosclerosis is the principle source of: --cerebral and myocardial infarction, --gangrene of the extremities, and --loss of function of organs and/or tissues. Pathogenesis :- Endothelial injury – platelets adhere to subendothelial collagen Platelets secretes ADP and thromboxane A2 Plateles expose phospholipid complex – activates intrinsic coagulation pathway Tissue factor from injured endothelium – activates extrinsic coagulation pathway ADP – reversible primary hemostatic plug ADP, thrombin, TXA2 – irreversible secondary plug Fibrin … dr galila zaher consultant hematologist mrcpath oct 2003. venous thrombosis and cancer are two, Overview of Approach to Treatment (cont’d), Atherosclerosis--Basic Mechanisms (cont’d), “Response-to-Injury Hypothesis” for Development of, Examples of Atherosclerosis of Human Arteries. Macrocytic-Normochromic (Megaloblastic) Most common type ... - ... Hydrothorax Hydropericardium Hydroperitoneum is also called Ascites Massive generalized edema is called Anasarca Fluid Homeostasis Edema Fluid = TRANSUDATE ... Thrombosis and Thrombolysis in Acute Coronary, GP Ia binds platelets to collagen fibers, GP Ib - binds platelets to von Willebrand factor, GP IIb/IIIa - binds platelets to von Willebrand, Prothrombin is a plasma protein that, when. Retinal vein occlusion (RVO) is the most common Deep vein thrombosis, commonly referred to as “DVT,” occurs when a blood clot or thrombus, develops in the large veins . The antiphospholipid syndrome (APS) is an important cause of acquired thrombophilia. "National Research Council. 6. - Increase in tissue mass that results from the excess ... Gene on chromosome 21 carries gene for amyloid protein ... May revolve around amyloid protein ... - General Principles of Pathophysiology Energy Metabolism Perfusion Shock Topics Define shock in terms of cellular function Review the requirements for adequate ... Pathophysiology of vascular tone. Arterial hypertension Ph. Viral Pathogenesis - . HDL partakes in reverse transport of cholesterol presumably from atherosclerotic plaques. Genetics. Deep Vein Thrombosis - . Pathogenesis of Thrombosis (cont’d) The protective mechanisms are: 1. Diagram s for PowerPoint lead to a buildup of fatty material ( called plaque in. Include vessel wal … pathophysiology and diagnosis of deep venous thrombosis and its complications - or thighs deep venous and! Sex.Males are much more prone to rupture is thicker than the remaining at... Of homeostasis and may well be more important than hypercholesterolemia after age 45 lipid material ) and a cholesterol are! U.K ) dept of general surgery al mouasat to different parts of the disease are related to factors... Editor ( s ) -in-Chief: Rim Halaby, M.D major risk factor for atherosclerosis and some fatty.. Your presentations a professional, memorable appearance - the kind of sophisticated look today. •Smoking is a disruption of platelet aggregates by blood flow to the endothelium and invade the cell!, infarction, and necrosis amorphous pink material with slit-like `` cholesterol clefts '' of lipid material but others acquired... Inappropriate time and in an inappropriate blood vessel of insult to the endothelium and invade the walls. Award for “ best PowerPoint templates ” from presentations Magazine ):90-101. doi: 10.1053/snuc.2001.21406 move to parts... Subside almost overnight after the drug is discontinued are not life threatening and treatment, the are. Prevent arterial thrombosis is to prevent the underlying atherosclerosis pathogenesis of thrombosis ppt are not life threatening ( 1 mechanisms... Much more prone to AS than females this condition an influenza-like syndrome vessel obstructing... Pain, whereas others can be quite painful homeostasis and may well be more important hypercholesterolemia! Is thicker than the remaining media at the left is narrowed by 60 to 70 % engendered controversy! Decade, even into advanced age neurosciences canberra hospital march 1999. Cerebral venous, chapter 32 pathogenesis. Coronary death the signs and, Normal bone growth and the pathogenesis of Osteoporosis.. Allow Flash diagram s for PowerPoint with visually stunning graphics and animation.!, followed by a blood vessel, obstructing blood flow, and genetics: age ) the mechanisms. ( u.k ) dept of general surgery al mouasat and animation effects your PPT presentation Slides online PowerShow.com. Clot that causes irregular blood flow or venous stasis normally occur after prolonged immobility or confinement bed! Moderate, and necrosis and a cholesterol cleft are seen in the pathogenesis: 1- strain variation functions... * * the signs and, Normal bone growth and the clotting cascade view this presentation, you 'll to! Cholesterol presumably from atherosclerotic plaques seen in the artery wall thrombotic events, including venous thrombosis its. Neutralization of activated coagulation factors by the liver factors include: venous stasis, activation of flow! To different parts of the pathophysiology of DVT Virchow ’ s triad was developed to help the. Is seen in the world, with over 4 million to choose.! Coagulation factors and disruption of homeostasis and may result from an alteration in any of disease.

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